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Home > Publications >
Design Projects
 Dr. David J. Klinke
II is currently an assistant professor in the Department of Chemical
Engineering in the WVU College of Engineering and Mineral Resources
(CEMR). In addition to his position in Chemical Engineering, he is an Adjunct
Assistant Professor of Microbiology, Immunology
& Cell Biology in the WVU School of Medicine and a
member of the Interdisciplinary
Research Center
for Immunopathology & Microbial Pathogenesis. He
received his Ph.D. in Chemical Engineering from Northwestern University
in 1998, where his research focus was on developing detailed chemical kinetic
models of Fischer-Tropsch synthesis. From 1999
until joining WVU in 2006, he provided strategic direction in developing
mathematical models of immunologic and metabolic diseases for one of the
commercial leaders in the emerging field of systems biology: Entelos, Inc. His current research applies the
computational tools of engineering analysis to biological problems in
immunology and cellular signal transduction.
This
Isn’t Your Parent’s Chemical Engineering
Here at West Virginia University,
Prof. Klinke’s research program builds on his
experience developing large-scale mathematical models of human pathophysiology. Building mathematical models of disease
is a collaborative effort between chemical engineers and life scientists to
extract information from the scientific literature to define, calibrate, and
validate these models experimentally. Understanding biology via computational
modeling is very similar to traditional research in chemical engineering. At
the most basic level, chemical engineering is a field in which basic science
data is integrated into computational frameworks. Traditionally, chemical engineering
integrates basic chemistry data into computational models to develop new chemical
products or processes. Moving forward into the 21st Century, there
is an urgent need for integrating basic biology data into computational
frameworks to understand disease pathophysiology
and aid in the rational design of novel therapeutics. It is our goal to become
leaders in the field of chemical engineering by fulfilling this urgent need.
Commitment
to Engineering Education
The Department of Chemical Engineering at West Virginia University has a long history of
excellence in undergraduate engineering education. In envisioning the skills
required in the 21st Century workplace, one of Prof. Klinke’s educational goals is to create a
cross-disciplinary learning experience for both undergraduates and graduate
students. Specifically, Dr. Klinke feels that
chemical engineers are uniquely positioned to apply creatively the computational
tools of engineering analysis to solve complex biological problems. However
as scientific disciplines become more complex, the terminology associated
with a particular discipline becomes more specialized. As a result, a big
hurdle in fostering cross-disciplinary collaborations is the lack of common
terminology. Thus, Prof. Klinke’s educational
efforts will reduce this barrier by focusing on three areas: 1) increasing
the frequency of interaction with researchers outside of the College of
Engineering and Mineral Resources through research collaborations with
colleagues in the WVU School of Medicine, 2) incorporating non-traditional
problems drawn from biology into standard chemical engineering courses, and
3) developing a new bioengineering course emphasizing cross-disciplinary
thinking.
If you
would like to join our group or find out more about Dr. Klinke’s
research, feel free to contact him at (304) 293-2111 ext 2432 or e-mail david.klinke(AT)mail.wvu.edu
Selected Publications
Refereed
journal articles
1. Klinke, D.J.; “An Age-Structured Model of Dendritic Cell Trafficking in the Lung”, Am J Physiol
Lung Cell Mol Physiol (2006 - accepted).
2. Klinke, D.J.; “The Ratio of P40 Monomer to Dimer is an Important Determinant of IL-12
Bioactivity”, J. Theor. Biology 240(2006)
323-335.
3. Broadbelt, L. J. and Klinke, D.
J., “Kinetics of Catalyzed Reactions – Heterogeneous” in Encyclopedia of Catalysis, Istvan T. Horvath (Editor-in-Chief), ISBN 0-471-24183-0, pp.
4772, December 2002.
4. Klinke, D. J. and Broadbelt, L.
J., “Construction of a Mechanistic Model of Fischer-Tropsch
Synthesis on Ni(111) and Co(0001) Surfaces”, Chem. Eng. Sci.
54(1999) 3379-3389.
5. Klinke, D. J.; Wilke, S.; and Broadbelt, L. J.; “A Theoretical Study of Carbon Chemisorption on Ni(111) and
Co(0001) Surfaces”; J. Catal. 178(1998) 540-554.
6.
Klinke, D. J. and Broadbelt,
L. J., “Mechanism Reduction during Computer Generation of Compact
Reaction Models”, AIChE J. 43(1997) 1828-1837.
Patents and Patent
Applications
1. Defranoux, N.A.; Dubnicoff,
T.B.; Klinke, D.J. II; Lewis, A.K.; Paterson, T.S.;
Ramanujan, S.; Shoda,
L.K.M.; Soderstrom, K.P.; Struemper,
H.K.; “Method and apparatus for computer modeling a joint”, US Patent #6,862,561.
2. Kelly,
S.D.; Klinke, D.J. II; Leong, C.; Lewis, A.K.; Okino, M.S.; Paterson, T.S.; Shoda,
L.K.M.; Stokes, C.; Struemper, H.K.; “Method
and apparatus for computer modeling of an adaptive immune response”, US Patent Application #20030104475.
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